Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a
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چکیده
منابع مشابه
Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a**
Src homology 2 (SH2) domains play a central role in signal transduction. Although many SH2 domains have been validated as drug targets, their structural similarity makes development of specific inhibitors difficult. The cancer-relevant transcription factors STAT5a and STAT5b are particularly challenging small-molecule targets because their SH2 domains are 93% identical on the amino acid level. ...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2015
ISSN: 0044-8249
DOI: 10.1002/ange.201410672